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KMID : 0043320160390121621
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Archives of Pharmacal Research
2016 Volume.39 No. 12 p.1621 ~ p.1627
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Penicilazaphilone C, a new antineoplastic and antibacterial azaphilone from the Marine Fungus Penicillium sclerotiorum
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Zho Song lin
Wang Min
Zhao Huan ge
Huang Yong hao
Lin Ying ying
Tan Guang hong
Chen Shung lin
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Abstract
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Two azaphilonidal derivatives [penicilazaphilones B (1) and C (2)], have been isolated from the fermented products of marine fungus strain Penicillium sclerotiorum M-22, penicilazaphilones C was a new compound. The compound’s structures were identified by the analysis of spectroscopic data including 1D and 2D NMR techniques (1H-NMR, 13C-NMR, COSY, HMQC, and HMBC). Biological evaluation revealed that penicilazaphilones B and C showed selective cytotoxicity against melanoma cells B-16 and human gastric cancer cells SGC-7901 with IC50 values of 0.291, 0.449 and 0.065, 0.720 mM, respectively, while exhibiting no significant toxicity to normal mammary epithelial cells M10 at the same concentration. Moreover, penicilazaphilones C also exhibited strong antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Escherichia coli with MIC values 0.037?0.150 mM, while penicilazaphilones B’s bacteriostatic action was weaker.
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KEYWORD
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Marine fungus, Penicillium sclerotiorum, Penicilazaphilones, Antibacterial activity, Cytotoxicity
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